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Promotions-/PhD-Stellen Stellenangebote

Chemistry PhD position at the Department of Nuclear Medicine TUM

In this project, we will synthesize and evaluate a novel class of small-molecule based ligands for targeted alpha therapy of prostate cancer.

Location:  Department of Nuclear Medicine and Central Institute for Translational Cancer Research (TranslaTUM), Klinikum rechts der Isar München; Ismaninger Straße 22, 81675 München

Start Date: Q1 2023

Project Area:    Targeted radioactive ligands hold great promise for treatment of advanced metastatic prostate cancer. In recent years, especially small molecules, labeled with alpha-emitting isotopes displayed a favorable treatment response in patients. However, also side effects are potentially higher, compared to standard therapy. In this project, we will synthesize and evaluate a novel class of small-molecule based ligands for targeted alpha therapy of prostate cancer.

Your Tasks:
•       Synthesis of peptides by solid-phase peptide synthesis
•       Synthesis of small organic molecules and conjugation
•       Development and optimization of radiolabeling procedures, using Actinium-225 and Fluorine-18
•       Evaluation of radiolabeled compounds using in vitro and ex vivo methods, e.g. on cells and tissue samples
•       Positron emission tomography-based imaging in animal models
•       Biodistribution studies in animal models

Our offer:
•       You will work in an international group of scientists and clinicians (Postdocs and PhD students with a background in chemistry, biology, veterinarians, physicians and technical assistants) with an excellent infrastructure and a strong focus on translational research
•       The salary will be according to TV-L E13 (65%)
•       You will be a member of the graduate program at TUM and will be able to participate in workshops (scientific and soft skills), seminars and career-building programs

The position require a high level of motivation, curiosity, and commitment to scientific excellence. We are looking for self-driven and independent candidates with a critical work ethic. The candidates should have a strong interest in applied and translational research. If you are interested and have a MSc. in Chemistry, Biochemistry, or similar qualification, please send a motivation letter and CV, including your possible start date. Applicants (m/f/d) should submit their electronic application to:
Contact details and further information:

Dr. Alexander Wurzer, alexander.wurzer[ät]tum.de

The University of Munich is an equal opportunity employer. The University welcomes and encourages interest from handicapped candidates.

Kategorien
Abschlussarbeiten Promotions-/PhD-Stellen Sonstige Stellenangebote Stellenangebote

Abgelaufen: Wissenschaftlicher Mitarbeiter (Master / Promotion / Postdoc) an der Johns Hopkins University

Kurzbeschreibung: Forschung im Bereich 3D Printing / Computational Design / Soft Materials

Description (eng.): The Mueller Lab (muellerlab.com) in the Whiting School of Engineering at Johns Hopkins University is inviting applications for multiple fully-funded positions for PhD students and Postdoctoral Fellows in the areas of 3D Printing and Additive Manufacturing, Computational Design and Optimization, and Mechanical Metamaterials. Additional positions may be available for Master’s theses.

The successful candidate(s) will develop novel 3D printing techniques, materials, and designs for Unmanned Aerial Vehicles (UAVs), prosthetics and exoskeletons, soft robotics, and other technologically advanced applications. The positions are in collaboration with other groups in the school, including the JHU Topology Optimization Group (ce.jhu.edu/topopt) and Mechanics of Soft Adaptive Materials Lab (nguyenlab.wse.jhu.edu), the Army Research Lab (arl.army.mil), and Bell Textron (bellflight.com).

The candidates must hold a master’s or PhD in Mechanical Engineering, Materials Science, Chemical Engineering, or a related discipline, and be experts in at least one of the following areas
 – Hardware-, material-, and software-design for 3D Printing, desirably with a focus on Direct-Ink Writing
 – Complex fluids, including non-Newtonian materials and rheological characterization
 – Active and multifunctional materials for application in (multistable) mechanical metamaterials
 – Computational design including topology optimization and numerical modeling

Interested applicants should email their application materials to Prof. Jochen Mueller (jochen@jhu.edu) and include (i) Curriculum Vitae with a complete publication list, (ii) contact information of at least three references, and, if applicable, (iii) three representative publications. Evaluation of candidates will begin immediately and continue until the positions are filled. Initial appointments will be for 12 months with the option to renew.

The Mueller Lab’s research is embedded at the intersection of Additive Manufacturing, Functional Matter, and Computational Design. We develop fabrication processes that enhance the structural complexity, material versatility, and throughput speed in 3D printing. We employ modern computational tools, such as numerical modeling, optimization, and machine learning to explore the new design space. The results are (meta)materials, structures, and processes with outstanding properties and novel functionality.

Contact: Prof. Jochen Mueller, jochen[ät]jhu.edu

Link: http://muellerlab.com

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Abgelaufen: Stellenausschreibungen im Bereich Oberflächenanaytik

Beachtet gerne die folgenden Stellenausschreibungen:

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Supramolecular chemistry to control the transport of molecules

About the Project:
Our group are interested in diverse applications of supramolecular chemistry, from coordination chemistry and self-assembly to polymer science and molecular photoswitches. For more information our group’s recent research, see https://bevesgroup.wordpress.com/publications/

This project is in collaboration with Prof. Palli Thordarson (@pallithordarson), Prof. Ayusman Sen Penn State (@ayusmansen) and Prof. Dean Astumian UMaine (@DeanAstumian).

This ARC-funded project aims to understand the mechanisms behind the directed bulk transport of molecules by controlled diffusion and flow linked by chemical reactions and chemical concentration gradients. This project will provide the first detailed experimental data to test proposed theories and produce a fundamental understanding of how molecules can undergo controlled transport. Expected outcomes include a new understanding of how molecules can be guided toward their desired targets, which could have applications in waste collection or sensing by concentrating analytes, and for understanding biological processes.

Skills gained include: Organic synthesis, host-guest chemistry, NMR spectroscopy and microfluidics experiments, optical microscopy, data analysis including kinetics modelling.

Required: BSc/MSc with Major in Chemistry; some experience with synthesis; UV-vis spectroscopy; interpreting NMR spectra. A willingness to learn some python coding and microscopy techniques, such as confocal microscopy.

PhD program: At UNSW our PhD program is 3.5 years of full time research, with no coursework requirements.

Eligibility:

· All nationalities are eligible.

· You must meet the English language requirements in order to apply. (https://www.unsw.edu.au/study/how-to-apply/english-language-requirements)

· You must have the equivalent of a 4 year undergraduate degree, with at least 9 months of research and an examined thesis (equivalent to UNSW 1st Class Honours).

Funding Notes

The available stipends will match the Australian Government Research Training Program scholarship (2022 rate = $28,854), plus relocation expenses.

How to apply: email A/Prof. Beves your CV, academic transcript (undergraduate and any postgraduate coursework grades) and the contact details for at least two (2) referees.

Link: Supramolecular chemistry to control the transport of molecules at UNSW Sydney on FindAPhD.com

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Photoredox catalysis by transition metal complexes

About the Project: Our group are interested in diverse applications of supramolecular chemistry, from coordination chemistry and self-assembly to polymer science and molecular photoswitches. For more information our group’s recent research, see https://bevesgroup.wordpress.com/publications/

In this project you will prepare coordination complexes and study their photophysical and electrochemical properties. From this you will understand how these can be most effectively applied to photoredox catalysis, and in multi-component molecular devices and machines. The work will involve a wide range of analytical techniques (NMR, MS, XRD, UV-vis etc) and will involve collaborations with external partners, including in ultrafast spectroscopy.

Skills gained include: Organic and inorganic chemistry synthesis, host-guest chemistry, NMR spectroscopy, optical (UV-vis and emission) spectroscopy, electrochemistry, mass spectrometry, and single crystal X-ray crystallography.

Required: BSc/MSc with Major in Chemistry; some experience with inorganic (coordination chemistry) synthesis; UV-vis spectroscopy; interpreting NMR spectra. A willingness to learn new techniques.

PhD program: At UNSW our PhD program is 3.5 years of full time research, with no coursework requirements.

Eligibility:
· You must meet the English language requirements in order to apply. (https://www.unsw.edu.au/study/how-to-apply/english-language-requirements)

· You must have the equivalent of a 4 year undergraduate degree, with at least 9 months of research and an examined thesis (equivalent to UNSW 1st Class Honours).

Funding Notes

The available stipends will match the Australian Government Research Training Program scholarship (2022 rate = $28,854), plus relocation expenses.

How to apply: email A/Prof. Beves your CV, academic transcript (undergraduate and any postgraduate coursework grades) and the contact details for at least two (2) referees.

Link: https://www.findaphd.com/phds/project/photoredox-catalysis-by-transition-metal-complexes/?p140445

Kategorien
Promotions-/PhD-Stellen Stellenangebote

PhD position at the Department of Neurology, University of Würzburg

Topic: Electrophysiological investigation of the pathogenicity of genetic variants in pain associated genes of patients with small fiber pathology an.

Tasks PhD candidate:
− Electrophysiological analysis (patch-clamp, multielectrode array) of patient-derived and sensory neurons in mono- and co-culture with Schwann cells
− HEK cell transfection and electrophysiological analysis
− Generation of patient-derived Schwann cells via iPSC
− Analysis of cultured Schwann cells by immunocytochemistry, qRT-PCR, and FACS

Prerequisites: We are seeking for a very industrious, eager, and reliable PhD candidate of Life Sciences or related Faculty who is enthusiastic about scientific work, and has experience in electrophysiology (patch-clamp) and cell culture. He/she is motivated to engage himself/herself in this exciting project and to become part of our enthusiastic research team!

Constellation: Our project will be performed by two PhD candidates who will team-up and work complementarily, however, on separate topics of the entire project.

Kontakt: Prof. Dr. N. Üçeyler, ueceyler_n[ät]ukw.de.

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Werkstudent (*) Manufacturing Technology Development

Stellenbeschreibung:
Arbeiten Sie mit innovativen 3Mern auf der ganzen Welt.
Die Wahl des richtigen Arbeitgebers ist eine Entscheidung, die Ihr Berufs- und Privatleben gleichermaßen erheblich beeinflusst. Daher ist es umso wichtiger, sich dabei jederzeit auf die Unterstützung des Unternehmens und dessen Führungskräfte verlassen zu können. Bei 3M werden Sie Teil eines globalen Multitechnologiekonzerns, der Ihre individuellen Stärken
wertschätzt, Ihre berufliche und persönliche Weiterentwicklung fördert und Ihnen Freiraum für Kreativität, Neugier und Eigeninitiative bietet. Treiben Sie gemeinsam mit 96.000 3Mern aus verschiedenen Kulturen & Nationalitäten nachhaltige Projekte, Ideen und Innovationen voran, die eines zum Ziel haben: das tägliche Leben eines jeden Einzelnen zu verbessern.

Ihr Beitrag zu unserem gemeinsamen Erfolg:
Als Werkstudent (*) Manufacturing Technology Development am Standort Seefeld (Bayern) haben Sie die Möglichkeit Ihr Wissen zielgerichtet einzusetzen, um unseren gemeinsamen Erfolg voranzubringen. Dabei umfasst Ihr Aufgabengebiet:
• Mitarbeit bei der Optimierung und Weiterentwicklung der
vorhandenen Produktionsprozesse hinsichtlich Produktqualität und
Produktivität
• Mitarbeit bei der Entwicklung neuer Herstellverfahren
• Planung (DoE), Durchführung und Auswertung von Experimenten im Labor
• Aufbau von Versuchen (Anlagen, Equipment, Steuerungen, Sensoren, Messtechnik)
• Interpretation der Ergebnisse und Dokumentation der gewonnenen Erkenntnisse

Kontakt: Rebecca Wilhelm, rebecca.wilhelm[ät]tum.de

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Atmospheric water harvesting: influence of defect sites in metal-organic frameworks on water uptake

Short Description:
While the amount of atmospheric water harvesting (AWH) MOFs is rapidly increasing over the last decade, the technical development of analysis platforms capable of in situ studying their performance is just starting. We developed a system based on (nonlinear) laser micro- and spectroscopy, that is capable of live monitoring the effect of heterogeneity on the AWH performance on the single crystal level.

Beschreibung:
Project:
Climate warming induced draughts are an increasing problem worldwide, threatening especially poor countries. Metal-organic frameworks (MOFs) are the most promising class of materials for harvesting large quantities of water from humid air. While the amount of atmospheric water harvesting (AWH) MOFs is rapidly increasing over the last decade, the technical development of analysis platforms capable of in situ studying their performance is just starting. We developed a system based on (nonlinear) laser micro- and spectroscopy, that is capable of live monitoring the effect of heterogeneity on the AWH performance on the single crystal level.

Qualification:
We are searching for candidates with:
• Background in inorganic / physical chemistry or physics
• Interest in optical spectroscopy techniques and imaging
• Prior experience in programming (Matlab / LabView) is an asset

Our offer:
We offer a multi-disciplinary and collaborative environment for working with advanced imaging and spectroscopy on the next generation of AWH MOFs. This is your opportunity to join our team in developing an automated gas exchange system to evaluate the in-situ sorption performance of novel AWH materials.

Kontaktperson: Dr. Evelyn Ploetz, evelyn.ploetz[ät]cup.lmu.de

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Aufreinigung des antimikrobiellen, antikrebs Peptids Lasioglossin aus Bienengift

Kurzbeschreibung:
Ziel des Forschungsprojekts PepBiR ist die Entwicklung eines innovativen Drug Delivery Systems für das antimikrobielle und antikrebs Peptid Lasioglossin III aus Bienengift. Durch spezifische Bindung mit Silica soll das Peptid nach der Expression in E.coli aufgereinigt werden. Durch Variation verschiedener Parameter soll eine Lasioglossin mit hoher Ausbeute und guter Reinheit erhalten werden. In einem weiteren Schritt wird das Prinzip auf Bienengift angewandt und überprüft.

Beschreibung:
Anforderungen: Strukturiertes, selbständiges und gewissenhaftes Arbeiten, Erfahrung im experimentellen Arbeiten und Aufreinigung von Proteinen (Äkta), Interesse an angewandter Forschung

Aufgaben: Zusammenarbeit im interdisziplinären Team, Expression von GFP-Lasioglossin mittels E.coli, Aufreinigung mittels Äkta und Silicasäule, Aufreinigung aus Bienengift, Reinheitsbestimmung mittels Gelelektrophorese und BCA-Assay

Kontakt: Chiara Turrina, c.turrina[ät]tum.de

Kategorien
Abschlussarbeiten Promotions-/PhD-Stellen Stellenangebote

Internships at Oncology Department at Novartis Institute for Biomedical Research (NIBR)

Kurzbeschreibung:
The Oncology Department of the Novartis Institute for Biomedical Research in Basel, Switzerland is currently looking for interns in the field of molecular and cellular biology. Positions are available for 6 months to work on different aspects of cancer biology.
You will be involved in cutting-edge research using the latest technologies in genetic manipulation, molecular cloning, cellular analyses and nucleic acid / protein characterization. You will join enthusiastic teams working on immune-oncology and signal transduction pathways to dissect the molecular functions of a number of candidate oncogenes/tumor suppressors in diverse cancer settings.

Beschreibung:
Your tasks will be:
– Design, execute and/or analyze experimental work with the supervision of different team members
– Contribute to lab / team organization and projects development
– Formulate and test additional hypothesis based on a large amount of internal data in different fields
– Provide accurate raw data documentation, evaluation and results interpretation

Requirements:
– M.Sc. degree in Molecular Biology (and related)
– Experience with mammalian cell culture and basic cell biology techniques (e.g. Western blotting) is required. FACS experience is preferred but not required.
– Interest / knowledge in cancer biology, immune-oncology and signal transduction are advantageous but not required.
– Good organizational skills with respect to planning, tracking and adherence to timelines
– Good communication, presentation and scientific writing skills
– Fluency in English is mandatory (oral & written)

Kontaktperson: Carlotta Costa, carlotta.costa[ät]novartis.com