Kategorie: Promotions-/PhD-Stellen

In this project, we will synthesize and evaluate a novel class of small-molecule based ligands for targeted alpha therapy of prostate cancer.

Location:  Department of Nuclear Medicine and Central Institute for Translational Cancer Research (TranslaTUM), Klinikum rechts der Isar München; Ismaninger Straße 22, 81675 München

Start Date: Q1 2023

Project Area:    Targeted radioactive ligands hold great promise for treatment of advanced metastatic prostate cancer. In recent years, especially small molecules, labeled with alpha-emitting isotopes displayed a favorable treatment response in patients. However, also side effects are potentially higher, compared to standard therapy. In this project, we will synthesize and evaluate a novel class of small-molecule based ligands for targeted alpha therapy of prostate cancer.

Your Tasks:
•       Synthesis of peptides by solid-phase peptide synthesis
•       Synthesis of small organic molecules and conjugation
•       Development and optimization of radiolabeling procedures, using Actinium-225 and Fluorine-18
•       Evaluation of radiolabeled compounds using in vitro and ex vivo methods, e.g. on cells and tissue samples
•       Positron emission tomography-based imaging in animal models
•       Biodistribution studies in animal models

Our offer:
•       You will work in an international group of scientists and clinicians (Postdocs and PhD students with a background in chemistry, biology, veterinarians, physicians and technical assistants) with an excellent infrastructure and a strong focus on translational research
•       The salary will be according to TV-L E13 (65%)
•       You will be a member of the graduate program at TUM and will be able to participate in workshops (scientific and soft skills), seminars and career-building programs

The position require a high level of motivation, curiosity, and commitment to scientific excellence. We are looking for self-driven and independent candidates with a critical work ethic. The candidates should have a strong interest in applied and translational research. If you are interested and have a MSc. in Chemistry, Biochemistry, or similar qualification, please send a motivation letter and CV, including your possible start date. Applicants (m/f/d) should submit their electronic application to:
Contact details and further information:

Dr. Alexander Wurzer, alexander.wurzer[ät]tum.de

The University of Munich is an equal opportunity employer. The University welcomes and encourages interest from handicapped candidates.

About the Project:
Our group are interested in diverse applications of supramolecular chemistry, from coordination chemistry and self-assembly to polymer science and molecular photoswitches. For more information our group’s recent research, see https://bevesgroup.wordpress.com/publications/

This project is in collaboration with Prof. Palli Thordarson (@pallithordarson), Prof. Ayusman Sen Penn State (@ayusmansen) and Prof. Dean Astumian UMaine (@DeanAstumian).

This ARC-funded project aims to understand the mechanisms behind the directed bulk transport of molecules by controlled diffusion and flow linked by chemical reactions and chemical concentration gradients. This project will provide the first detailed experimental data to test proposed theories and produce a fundamental understanding of how molecules can undergo controlled transport. Expected outcomes include a new understanding of how molecules can be guided toward their desired targets, which could have applications in waste collection or sensing by concentrating analytes, and for understanding biological processes.

Skills gained include: Organic synthesis, host-guest chemistry, NMR spectroscopy and microfluidics experiments, optical microscopy, data analysis including kinetics modelling.

Required: BSc/MSc with Major in Chemistry; some experience with synthesis; UV-vis spectroscopy; interpreting NMR spectra. A willingness to learn some python coding and microscopy techniques, such as confocal microscopy.

PhD program: At UNSW our PhD program is 3.5 years of full time research, with no coursework requirements.

Eligibility:

· All nationalities are eligible.

· You must meet the English language requirements in order to apply. (https://www.unsw.edu.au/study/how-to-apply/english-language-requirements)

· You must have the equivalent of a 4 year undergraduate degree, with at least 9 months of research and an examined thesis (equivalent to UNSW 1^st Class Honours).

Funding Notes

The available stipends will match the Australian Government Research Training Program scholarship (2022 rate = $28,854), plus relocation expenses.

How to apply: email A/Prof. Beves your CV, academic transcript (undergraduate and any postgraduate coursework grades) and the contact details for at least two (2) referees.

Link: Supramolecular chemistry to control the transport of molecules at UNSW Sydney on FindAPhD.com

About the Project: Our group are interested in diverse applications of supramolecular chemistry, from coordination chemistry and self-assembly to polymer science and molecular photoswitches. For more information our group’s recent research, see https://bevesgroup.wordpress.com/publications/

In this project you will prepare coordination complexes and study their photophysical and electrochemical properties. From this you will understand how these can be most effectively applied to photoredox catalysis, and in multi-component molecular devices and machines. The work will involve a wide range of analytical techniques (NMR, MS, XRD, UV-vis etc) and will involve collaborations with external partners, including in ultrafast spectroscopy.

Skills gained include: Organic and inorganic chemistry synthesis, host-guest chemistry, NMR spectroscopy, optical (UV-vis and emission) spectroscopy, electrochemistry, mass spectrometry, and single crystal X-ray crystallography.

Required: BSc/MSc with Major in Chemistry; some experience with inorganic (coordination chemistry) synthesis; UV-vis spectroscopy; interpreting NMR spectra. A willingness to learn new techniques.

PhD program: At UNSW our PhD program is 3.5 years of full time research, with no coursework requirements.

Eligibility:
· You must meet the English language requirements in order to apply. (https://www.unsw.edu.au/study/how-to-apply/english-language-requirements)

· You must have the equivalent of a 4 year undergraduate degree, with at least 9 months of research and an examined thesis (equivalent to UNSW 1^st Class Honours).

Funding Notes

The available stipends will match the Australian Government Research Training Program scholarship (2022 rate = $28,854), plus relocation expenses.

How to apply: email A/Prof. Beves your CV, academic transcript (undergraduate and any postgraduate coursework grades) and the contact details for at least two (2) referees.

Link: https://www.findaphd.com/phds/project/photoredox-catalysis-by-transition-metal-complexes/?p140445

Topic: Electrophysiological investigation of the pathogenicity of genetic variants in pain associated genes of patients with small fiber pathology an.

Tasks PhD candidate:
− Electrophysiological analysis (patch-clamp, multielectrode array) of patient-derived and sensory neurons in mono- and co-culture with Schwann cells
− HEK cell transfection and electrophysiological analysis
− Generation of patient-derived Schwann cells via iPSC
− Analysis of cultured Schwann cells by immunocytochemistry, qRT-PCR, and FACS

Prerequisites: We are seeking for a very industrious, eager, and reliable PhD candidate of Life Sciences or related Faculty who is enthusiastic about scientific work, and has experience in electrophysiology (patch-clamp) and cell culture. He/she is motivated to engage himself/herself in this exciting project and to become part of our enthusiastic research team!

Constellation: Our project will be performed by two PhD candidates who will team-up and work complementarily, however, on separate topics of the entire project.

Kontakt: Prof. Dr. N. Üçeyler, ueceyler_n[ät]ukw.de.

Stellenbeschreibung:
Arbeiten Sie mit innovativen 3Mern auf der ganzen Welt.
Die Wahl des richtigen Arbeitgebers ist eine Entscheidung, die Ihr Berufs- und Privatleben gleichermaßen erheblich beeinflusst. Daher ist es umso wichtiger, sich dabei jederzeit auf die Unterstützung des Unternehmens und dessen Führungskräfte verlassen zu können. Bei 3M werden Sie Teil eines globalen Multitechnologiekonzerns, der Ihre individuellen Stärken
wertschätzt, Ihre berufliche und persönliche Weiterentwicklung fördert und Ihnen Freiraum für Kreativität, Neugier und Eigeninitiative bietet. Treiben Sie gemeinsam mit 96.000 3Mern aus verschiedenen Kulturen & Nationalitäten nachhaltige Projekte, Ideen und Innovationen voran, die eines zum Ziel haben: das tägliche Leben eines jeden Einzelnen zu verbessern.

Ihr Beitrag zu unserem gemeinsamen Erfolg:
Als Werkstudent (*) Manufacturing Technology Development am Standort Seefeld (Bayern) haben Sie die Möglichkeit Ihr Wissen zielgerichtet einzusetzen, um unseren gemeinsamen Erfolg voranzubringen. Dabei umfasst Ihr Aufgabengebiet:
• Mitarbeit bei der Optimierung und Weiterentwicklung der
vorhandenen Produktionsprozesse hinsichtlich Produktqualität und
Produktivität
• Mitarbeit bei der Entwicklung neuer Herstellverfahren
• Planung (DoE), Durchführung und Auswertung von Experimenten im Labor
• Aufbau von Versuchen (Anlagen, Equipment, Steuerungen, Sensoren, Messtechnik)
• Interpretation der Ergebnisse und Dokumentation der gewonnenen Erkenntnisse

Kontakt: Rebecca Wilhelm, rebecca.wilhelm[ät]tum.de

Short Description:
While the amount of atmospheric water harvesting (AWH) MOFs is rapidly increasing over the last decade, the technical development of analysis platforms capable of in situ studying their performance is just starting. We developed a system based on (nonlinear) laser micro- and spectroscopy, that is capable of live monitoring the effect of heterogeneity on the AWH performance on the single crystal level.

Beschreibung:
Project:
Climate warming induced draughts are an increasing problem worldwide, threatening especially poor countries. Metal-organic frameworks (MOFs) are the most promising class of materials for harvesting large quantities of water from humid air. While the amount of atmospheric water harvesting (AWH) MOFs is rapidly increasing over the last decade, the technical development of analysis platforms capable of in situ studying their performance is just starting. We developed a system based on (nonlinear) laser micro- and spectroscopy, that is capable of live monitoring the effect of heterogeneity on the AWH performance on the single crystal level.

Qualification:
We are searching for candidates with:
• Background in inorganic / physical chemistry or physics
• Interest in optical spectroscopy techniques and imaging
• Prior experience in programming (Matlab / LabView) is an asset

Our offer:
We offer a multi-disciplinary and collaborative environment for working with advanced imaging and spectroscopy on the next generation of AWH MOFs. This is your opportunity to join our team in developing an automated gas exchange system to evaluate the in-situ sorption performance of novel AWH materials.

Kontaktperson: Dr. Evelyn Ploetz, evelyn.ploetz[ät]cup.lmu.de

Kurzbeschreibung:
Ziel des Forschungsprojekts PepBiR ist die Entwicklung eines innovativen Drug Delivery Systems für das antimikrobielle und antikrebs Peptid Lasioglossin III aus Bienengift. Durch spezifische Bindung mit Silica soll das Peptid nach der Expression in E.coli aufgereinigt werden. Durch Variation verschiedener Parameter soll eine Lasioglossin mit hoher Ausbeute und guter Reinheit erhalten werden. In einem weiteren Schritt wird das Prinzip auf Bienengift angewandt und überprüft.

Beschreibung:
Anforderungen: Strukturiertes, selbständiges und gewissenhaftes Arbeiten, Erfahrung im experimentellen Arbeiten und Aufreinigung von Proteinen (Äkta), Interesse an angewandter Forschung

Aufgaben: Zusammenarbeit im interdisziplinären Team, Expression von GFP-Lasioglossin mittels E.coli, Aufreinigung mittels Äkta und Silicasäule, Aufreinigung aus Bienengift, Reinheitsbestimmung mittels Gelelektrophorese und BCA-Assay

Kontakt: Chiara Turrina, c.turrina[ät]tum.de