The research unit „Chemical Oceanography“ of the research division „Marine Biogeochemistry“ at GEOMAR invites applications for a Ph.D. position on the development of a chemical sensor for the measurement of dissolved inorganic carbon (DIC) in seawater.The candidate will work in thelarge consortium ’AIMS3’that forms part of the German DAM (Deutsche Allianz Meeresforschung) Mission on ‘Marine CarbonSinksinDecarbonizationPathways’. The DAM Mission will explore ocean carbon sink options and develop environmental monitoring approaches as part of thedecarbonization strategy. AIMS3 will develop improved environmental monitoring technologies for off-shore carbon capture and storage(CCS)sites, and will explore the possibility of CO2storage in deep ocean basalts. The candidate willdesign, develop and demonstrate a DIC sensor for monitoring CCS sites for potential CO2leaks. The PhD project will be conducted in close collaboration with a local marine technology company.The project will involve optimisation of sensor chemistry and detection technology, sensor miniaturisation and integration into existing physical sensor systems produced by the company. Laboratory and field testing and demonstrations form part of the project. The candidate will work closely with Prof. Dr. Eric Achterbergand Dr Mario Esposito, the local company, and other partners in AIMS3. The candidate will become part of the German DAM Mission ‘Marine Carbon Sinks in Decarbonization Pathways’, and in particular in the AIMS3 project. Regular fieldwork opportunities, including research cruises, will form part of the PhD project for testing and demonstration purposes. We expect the candidate to enrol in the marine science post-graduate school in Kiel, ISOS.
Kategorie: Promotions-/PhD-Stellen
Stellenangebote für Promotionen
Beschreibung:
Die/der uns bei der molekularen/biochemischen Untersuchung der Funktion des multifunktionalen TIMP-1 (Tissue Inhibitor of Metalloproteinases-1) Moleküls als Proteaseinhibitor oder, in seiner neuen Funktion, als Zytokin unterstützt.
TIMP-1 spielt bei sehr vielen immunassoziierten Krankheiten (Entzündungen, Krebs) eine wichtige Rolle. Mit Ihrer Hilfe möchten wir die Rolle von TIMP-1 an Hand geeigneter Zellkultursysteme, Mausmodelle und einem breiten Spektrum molekularbiologisch-biochemischer Methoden (Signalwege, Zellverhalten) weiter untersuchen.
Mitwirkung an aktuellen Publikationsvorhaben ist ausdrücklich erwünscht und wird gefördert.
Das Projekt wird durch Mittel der Deutschen Forschungsgemeinschaft (DFG) finanziert und gefördert.
Ihr Profil:
– Kenntnisse und Interesse am Erlernen oder der Optimierung Ihrer Kenntnisse bei der Reinigung von rekombinanten Proteinen und im Umgang mit FPLC-Systemen (Äkta avant, pure etc.)
– Interesse am Erlernen oder der Optimierung Ihrer Kenntnisse in gängigen Labortechniken (Zellkultur, Immunfärbungen, Durchflusszytometrie, ELISA, etc.) und Bioinformatik.
– Breites naturwissenschaftliches Interesse
– Routinierter Umgang mit gängiger Software (MS-Office)
– Deutsch- und Englischkenntnisse
– Lernbereitschaft und Teamfähigkeit
Wir bieten Ihnen:
– Promotion zum naturwissenschaftlichen Doktor (Dr.rer.nat)
Eine abwechslungsreiche und fachlich anspruchsvolle Tätigkeit an modern ausgestatteten Arbeitsplätzen
– Umfassende Einarbeitung durch erfahrene und qualifizierte Kollegen
– Arbeiten mitten in München am Max-Weber-Platz mit sehr guter Erreichbarkeit durch öffentliche Verkehrsmittel und Vergünstigung durch Job-Tickets für MVV, MVG, Deutsche Bahn, Meridian und BOB
– Vermögenswirksame Leistungen und betriebliche Altersversorgung
– Leistungsgerechte Vergütung nach TV-L zuzüglich der attraktiven
– Leistungen des öffentlichen Dienstes
Kontakperson:
Prof. Dr. Achim Krüger
Klinikum rechts der Isar der Technischen Universität München
Ismaninger Straße 22
81675 München
E-Mail: Achim.Krueger[ät]tum.de
Description:
Two open PhD positions are available at the Institute of Molecular Immunology & Experimental Oncology, Technical University of Munich.The institute addresses important questions about the regulation of immunity against hepatotropic infections and tumors in mice and men. Preclinical models are applied to investigate detailed mechanistic principles about anti-viral and anti-cancer immunity. Both projects are based on the identification of a novel T cell population that has tissue-destructive function (Dudek et al. Nature 2021). The third-party funded projects (DFG and Helmholtz) will investigatevirus-specific immunity against hepatitis B Virus infection and SARS-CoV-2 infection and how tissue-destructive T cells contribute to immune surveillance or immune pathology.
Short:
The Zeymer group is looking for a dedicated and talented PhD student, who is interested in protein engineering, artificial metalloenzymes, and protein dynamics. The project is fully funded through the Collaborative Research Center „SFB1035“, a consortium of biochemists, structural biologists, and biophysicists at TUM and beyond focusing on the “Control of Protein Function by Conformational Switching”. If you are enthusiastic about science and wish to work on an exciting and challenging research project at the interface between Biochemistry and Biophysics, please apply directly by e-mail to Prof. Dr. Cathleen Zeymer.
Detailed:
The Zeymer Lab is a member of the Department of Chemistry and the newly established Center for Functional Protein Assemblies at TU Munich, Germany. We combine rational design and directed evolution to engineer artificial metalloenzymes and study their structure and molecular mechanism with various biophysical techniques.
We are currently looking for a dedicated and talented PhD student, who is interested in engineering conformational dynamics in a lanthanide-dependent de novo enzyme. The project is fully funded through the Collaborative Research Center SFB1035, a consortium of biochemists, structural biologists, and biophysicists focusing on the “Control of Protein Function by Conformational Switching”.
Candidates with a Master’s degree in Biochemistry, Chemistry, or Biology, who are highly motivated to learn about enzyme engineering, directed evolution, protein structure and dynamics are encouraged to apply. Previous practical experience in molecular cloning, protein expression and purification, as well as handling and characterizing (metallo-)enzymes will be of benefit.
If you are enthusiastic about science and wish to work on an exciting and challenging research project at the interface between Biochemistry and Biophysics, please apply directly by e-mail to Prof. Dr. Cathleen Zeymer. The application should include a cover letter, CV, transcript of records, and contact details to request two reference letters.
Contact:
E-Mail: cathleen.zeymer[ät]tum.de
Master’s thesis and PhD projects in several areas at Max Planck Institute of Biochemistry availabe. We hope to recruit students with a background in physics, biochemistry, or a related field, who have a strong interest in dynamic studies of biological processes using structural and single-molecule approaches. Skills in protein biochemistry, programming, and a basic knowledge of kinetic analysis would be ideal, but are not required. Applicants should have a strong desire to pursue a multidisciplinary collaborative project working closely with others. Creative and independent thinking will be key for the successful completion of the projects.
Imaging the macromolecular complexes that reshape and remake chromosomes
Background: The survival of all organisms depends on the faithful duplication and transfer of genetic material from one generation to the next. In cells, this process is performed by large macromolecular complexes, known as replisomes, which couple the unpackaging of parental DNA with the synthesis of new daughter strands. To ensure genome integrity, these sophisticated molecular machines must coordinate events over a broad range of time and length scales, from the breaking and reformation of chemical bonds within DNA polymerases to the large-scale structural rearrangements of chromosomes. We seek to define the operating principles that guide replisome assembly and function on complex cellular substrates. We are particularly interested in understanding how replication overcomes the numerous structurally diverse obstacles frequently encountered on chromosomes.
Methods: We use a combination of structural, biochemical, and imaging techniques to directly visualize the spatial and conformational dynamics of critical replication intermediates. These efforts range from detailed biophysical investigations of individual complexes and interactions to studies of completely reconstituted replisomes in vitro (E. coli, S. Cerevisiae). We use cutting-edge single-molecule imaging approaches that provide high spatial and temporal resolution to study the dynamics of single replisomes.
We are currently offering Master’s thesis and PhD projects in several areas. First, we are developing single-molecule approaches to directly visualize the disassembly and reassembly of nucleosomes during replication. In the context of this project, we are seeking students to work in a team to purify histone chaperones and remodelers and exploit several chemically diverse fluorophore labeling strategies for single-molecule visualization. Second, we are looking for students to help in our studies of replication and transcription conflicts. Of particular interest are rare events were RNA polymerase bypasses replication factors. Finally, for those interested in software development and biophysics, we are developing ultra-high-throughput approaches to hunt for rare but deadly DNA breaks by topoisomerases.
Please get in touch for further details and to hear about other currently offered projects.
Our lab is located at the Max Planck Institute of Biochemistry. You can find us on the web at http://www.biochem.mpg.de/duderstadt and https://duderstadtlab.org
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An der Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRM II) in Garching bei München.