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Abschlussarbeiten Stellenangebote

Master thesis molecular biology/ pharmacy/ biochemistry

  • Are you studying molecular biology/ pharmacy/ biochemistry?
  • Are you looking for a young and motivated group to conduct your Master´s thesis in?
  • Do you want to work in an interdisciplinary team?
  • Are you interested in investigating therapy-resistance in highly advanced cancer cells?
    YOU WILL BE:
  • Using a screening platform to identify pathways that are involved in cancer progression.
  • Testing new compounds in cell culture models for advanced and metastatic cancers to find potential therapy targets.
  • Learning about cancer cell biology and improving your skills in methods such as cell culture, viability assays, click chemistry, SDS-PAGE, Western Blot and FACS.
    INTERESTED?
    Feel free to send us any questions that you may have or directly apply with your CV!
    To:
    david.konrad[ät]cup.lmu.de
    and
    anna.milton[ät]cup.lmu.de
    you can find our website here
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Abschlussarbeiten Stellenangebote

BSc Thesis Project in Mass Spectrometry Imaging (Analytical Chemistry)

We are looking for a BSc student for a 3 month thesis project entitled “The effect of different wash steps on the tissue metabolome in DESI-MSI”. Wash steps are frequently applied to tissue sections prior to mass spectrometry imaging (MSI) analysis to increase sensitivity for some compounds through the removal of some of the matrix compounds (for instance a xylene wash to remove lipids can increase abundance of highly hydrophilic compounds such as adenosine. However, a systematic assessment of the changes in the metabolome by DESI-MSI has not been performed yet. The student will test different polar and non polar wash solutions, optimise the wash duration, and perform MSI analysis to characterise these changes.

You are our right candidate if you’re interested in biomedical applications of mass spectrometry, especially mass spectrometry imaging. We will work with tissue specimen, cryosectioning, classical histological tissue stains (H&E, IHC) as well as state-of-the-art MSI using the ambient method Desorption Electrospray Ionisation (DESI). This project requires a systematic way of working and attention to detail.

Please send your application including your CV and a transcript of records to: nicole.strittmatter[ät]tum.de. Please supply a reference if possible.

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Abschlussarbeiten Stellenangebote

MSc Thesis Project in Mass Spectrometry Imaging (Analytical Chemistry)

The professorship of Analytical Chemistry (Prof. Strittmatter) I looking for a master student for a 6 month thesis project entitled “Development of small inhibitor-based protein stains for mass spectrometry imaging”. You will learn state-of-the-art imaging ambient and imaging technologies, especially Desorption Electrospray Ionisation on a Orbitrap mass spectrometer and get acquainted with molecular imaging technologies. The project will focus on the development of novel protein stains where we will aim to stain proteins with matching small molecule inhibitors instead of the commonly deployed antibodies. We will use PARP1 and EGFR as model systems.

You are our right candidate if you’re interested in biomedical applications of mass spectrometry, especially mass spectrometry imaging. We will work with tissue specimen, cryosectioning, classical histological tissue stains (H&E, IHC) as well as developing our own staining workflow. This is a high risk, high gain project that will require independent, creative thinking and a systematic way of working.

Please send your application including your CV, names and contact information for 2 references, and a transcript of records to: nicole.strittmatter[ät]tum.de

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Abschlussarbeiten Promotions-/PhD-Stellen Sonstige Stellenangebote Stellenangebote

Abgelaufen: Wissenschaftlicher Mitarbeiter (Master / Promotion / Postdoc) an der Johns Hopkins University

Kurzbeschreibung: Forschung im Bereich 3D Printing / Computational Design / Soft Materials

Description (eng.): The Mueller Lab (muellerlab.com) in the Whiting School of Engineering at Johns Hopkins University is inviting applications for multiple fully-funded positions for PhD students and Postdoctoral Fellows in the areas of 3D Printing and Additive Manufacturing, Computational Design and Optimization, and Mechanical Metamaterials. Additional positions may be available for Master’s theses.

The successful candidate(s) will develop novel 3D printing techniques, materials, and designs for Unmanned Aerial Vehicles (UAVs), prosthetics and exoskeletons, soft robotics, and other technologically advanced applications. The positions are in collaboration with other groups in the school, including the JHU Topology Optimization Group (ce.jhu.edu/topopt) and Mechanics of Soft Adaptive Materials Lab (nguyenlab.wse.jhu.edu), the Army Research Lab (arl.army.mil), and Bell Textron (bellflight.com).

The candidates must hold a master’s or PhD in Mechanical Engineering, Materials Science, Chemical Engineering, or a related discipline, and be experts in at least one of the following areas
 – Hardware-, material-, and software-design for 3D Printing, desirably with a focus on Direct-Ink Writing
 – Complex fluids, including non-Newtonian materials and rheological characterization
 – Active and multifunctional materials for application in (multistable) mechanical metamaterials
 – Computational design including topology optimization and numerical modeling

Interested applicants should email their application materials to Prof. Jochen Mueller (jochen@jhu.edu) and include (i) Curriculum Vitae with a complete publication list, (ii) contact information of at least three references, and, if applicable, (iii) three representative publications. Evaluation of candidates will begin immediately and continue until the positions are filled. Initial appointments will be for 12 months with the option to renew.

The Mueller Lab’s research is embedded at the intersection of Additive Manufacturing, Functional Matter, and Computational Design. We develop fabrication processes that enhance the structural complexity, material versatility, and throughput speed in 3D printing. We employ modern computational tools, such as numerical modeling, optimization, and machine learning to explore the new design space. The results are (meta)materials, structures, and processes with outstanding properties and novel functionality.

Contact: Prof. Jochen Mueller, jochen[ät]jhu.edu

Link: http://muellerlab.com

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Abschlussarbeiten Praktika Sonstige Stellenangebote Stellenangebote

Abgelaufen: Inbetriebnahme und experimentelle Untersuchung eines Flugstromvergasers zur Erzeugung von Synthesegas aus Biomasse/Reststoffen

Kurzbeschreibung: Semesterarbeit/Masterarbeit
Themengebiet: thermo-chemische Konversion von Biomassen/Reststoffen zu Synthesegas (H2, CO)
– Aufbau und Inbetriebnahme von Anlagenteilen eines Flugstromvergasers
– Versuchsbetrieb und Experimente im Technikumsmaßstab zur Boudouard-Reaktion und zur heterogenen Wassergas-Shift-Reaktion
– Auswertung der Ergebnisse

Beschreibung: Eine vielversprechende Möglichkeit zur stofflichen Nutzung von Biomasse besteht in der Flugstromvergasung. Dadurch kann hochqualitatives Synthesegas (H2 & CO) hergestellt werden, welches anschließend in katalytischen Synthesen beispielsweise zu „grünem“ Methanol, FT-Produkten oder anderen chemischen Energieträgern umgewandelt werden kann. Um großtechnische Vergasungsanlagen kommerziell realisieren zu können, ist die Kenntnis des Umsatzverhaltens und der Produktgasqualität von großer Bedeutung. Hierzu werden im Rahmen des VERENA-Projektes (https://www.epe.ed.tum.de/es/forschung/projekte/verena/) verschiedene Biomassen in einem atmosphärischen Flugstromvergaser (BabiTER) bei Temperaturen von bis zu 1600 °C erforscht.

Im Rahmen dieser Arbeit soll eine Technikumsanlage zur Erzeugung von Synthesegas in Betrieb genommen werden. Hierfür sind diverse Anlagenteile wie etwa die Brennstoffdosierleitung, eine Verdampfereinheit und der Reaktor aufzubauen sowie zu erproben. Anschließend sind biogene Reststoffe experimentell zu untersuchen und das Umsatzverhalten, die Produktgaszusammensetzung und der Kaltgaswirkungsgrad in Abhängigkeit der Vergasungsmedien, der Temperatur und der Partikelverweilzeit zu bestimmen. Im Fokus stehen hier insbesondere differentielle Vergasungsversuche zur Boudouard-Reaktion oder zur heterogenen Wassergas-Shift-Reaktion. Die Ergebnisse sind anschließend grafisch aufzubereiten und schriftlich festzuhalten.

Arbeitspakete:
– Literaturstudie zur thermo-chemischen Vergasung von Biomassen
– Umbauarbeiten an der Technikumsanlage
– Planung, Durchführung und Auswertung von Experimenten zur Flugstromvergasung
– Dokumentation der Arbeiten

Voraussetzungen:
– Interesse und Spaß an der Rohstoff- und Energiewende
– Handwerkliches Geschick von Vorteil
– Experimentelle Vorerfahrung von Vorteil
– Selbstständige, teamorientierte und zuverlässige Arbeitsweise

Kontaktperson: Weiss Naim, weiss.naim[ät]tum.de

Link: https://www.epe.ed.tum.de/es/forschung/projekte/verena/

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Abschlussarbeiten Stellenangebote

Master’s thesis: Application of genetically encoded tension sensor modules to pancreatic cancer organoids

Kurzbeschreibung:
The aim of this thesis is to establish a new method for the measurement of molecular forces by applying tension sensors based on FRET to pancreatic cancer organoids. Confocal microscopy and digital imaging processing and analysis will be employed to understand how mechanical forces lead to structure formation processes in organmorphogenesis.

Your Profile:
• Surpassing grades in your master’s program in biology, (bio)chemistry, biotechnology, physics, or related scientific program
• Genuine interest in the powerful applications of cancer organoids and FLIM-FRET imaging
• Previous experience with fluorescence microscopy
• Advanced programming skills (Phython, matlab,…) for image data processing
• The ability to be self-motivated and to work independently within an interdisciplinary team of biotechnologists and physicist
• English language and organizational skills

Contact: M.Sc. Sophie Kurzbach, sophie.kurzbach[ät]tum.de

Link: https://www.bauschlab.org/

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Abschlussarbeiten Allgemein Stellenangebote

Bachelor’s thesis: Application of genetically encoded tension sensor modules to pancreatic cancer organoid

Short description:
The aim of this thesis is to establish a new method for the measurement of molecular forces by applying tension sensors based on FRET to pancreatic cancer organoids. Confocal microscopy and digital imaging processing and analysis will be employed to understand how mechanical forces lead to structure formation processes in organmorphogenesis.

Your Profile:
• Surpassing grades in your bachelor’s program in biology, (bio)chemistry, molecular biotechnology, physics, or related scientific program
• Genuine interest in the powerful applications of cancer organoids combined with FLIM-FRET imaging
• Previous experience with microscopy, fiji (imageJ) data analysis, mammalian cell culture
• The ability to be self-motivated and to work within an interdisciplinary team of biotechnologists and physicist
• English language and organizational skills

Techniques:
Mammalian cell culture, organoid culture, immunostainings, FACS, fluorescence and FLIM imaging, image processing

Contact: M.Sc. Sophie Kurzbach, sophie.kurzbach[ät]tum.de

Link: https://www.bauschlab.org/

Kategorien
Abschlussarbeiten Praktika Stellenangebote

BA / SA / MA: Potentialkontrollierte Membranchromatographie – Setup Design

Kurzbeschreibung:
Entwicklung eines neuen Setups für die Potentialkontrollierte Membranchromatographie.
Aufgaben: Entwicklung eines Membranmoduls, Simulation der Strömungseigenschaften, Inbetriebnahme an einer präparativen Chromatographieanlage
Anforderungen: Kreativität und handwerkliches Geschick, Spaß an angewandter Forschung, Von Vorteil: Erste Kenntnisse in CAD und Comsol

Beschreibung:
Ziel dieses Forschungsprojektes ist die Entwicklung eines neuartigen Chromatographieprozesses unter Einsatz von leitfähigen Membranen. Diese können in ihrer Ladung und folglich ihrem Bindecharakter beeinflusst werden und ermöglichen somit eine potentialkontrollierte Elution des Zielmoleküls. Dadurch kann die Biomolekülaufreinigung nicht nur effizienter und kostengünstiger sondern auch nachhaltiger erfolgen.
In dieser Abschlussarbeit soll ein neues Membranmodul für den Einsatz an einer präparativen Chromatographieanlage mittels CAD entworfen werden. Die Strömungseigenschaften des Moduls spielen hierbei eine entscheidende Rolle und sollen anschließend simulativ untersucht werden. In einem weiteren Schritt soll das entwickelte Modul an einer präparativen Chromatographieanlage in Betrieb genommen und auf seine Eignung untersucht werden.

Kontaktperson: Dennis Röcker, d.roecker[ät]tum.de

Link: https://www.epe.ed.tum.de/stt/selektive-trenntechnik/

Kategorien
Abschlussarbeiten Praktika Stellenangebote

Carbon capture & storage: analysis and characterization of biochar production pathways

Short description:
At the Laboratory of Chemical Process Engineering, a new project about carbon capture and storage has recently started. The overall aim of the project is to reduce the amount of carbon in the atmosphere by developing a suitable long-term carbon storage in Bavaria. There are various carbon sources, such as CO2 from air, minerals, organic waste, crops, algae and further sorts of biomass. All of them are carbon-containing resources and, therefore, must be considered as possible feedstock for carbon storage. To achieve a higher carbon content and higher density of these compounds, processes are sought to convert them to long-term carbon storage materials.
Within the scope of this project, biochar as a feasible storage material should be analyzed. Special interest applies to the characterization of different production pathways concerning yield, energy and water consumption and required temperatures for each production pathway. For more details, contact the supervisor.

Description: Good knowledge of German or English language is required, as well as interest in carbon capture and storage techniques. Priorknowledge in any of the following topics is appreciated but not required: LCA, process engineering, reaction kinetics, thermodynamics, and physical chemistry. Good support and training will be provided.

Kontaktperson: Natalie Rosen, natalie.rosen[ät]tum.de

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Abschlussarbeiten Promotions-/PhD-Stellen Stellenangebote

Internships at Oncology Department at Novartis Institute for Biomedical Research (NIBR)

Kurzbeschreibung:
The Oncology Department of the Novartis Institute for Biomedical Research in Basel, Switzerland is currently looking for interns in the field of molecular and cellular biology. Positions are available for 6 months to work on different aspects of cancer biology.
You will be involved in cutting-edge research using the latest technologies in genetic manipulation, molecular cloning, cellular analyses and nucleic acid / protein characterization. You will join enthusiastic teams working on immune-oncology and signal transduction pathways to dissect the molecular functions of a number of candidate oncogenes/tumor suppressors in diverse cancer settings.

Beschreibung:
Your tasks will be:
– Design, execute and/or analyze experimental work with the supervision of different team members
– Contribute to lab / team organization and projects development
– Formulate and test additional hypothesis based on a large amount of internal data in different fields
– Provide accurate raw data documentation, evaluation and results interpretation

Requirements:
– M.Sc. degree in Molecular Biology (and related)
– Experience with mammalian cell culture and basic cell biology techniques (e.g. Western blotting) is required. FACS experience is preferred but not required.
– Interest / knowledge in cancer biology, immune-oncology and signal transduction are advantageous but not required.
– Good organizational skills with respect to planning, tracking and adherence to timelines
– Good communication, presentation and scientific writing skills
– Fluency in English is mandatory (oral & written)

Kontaktperson: Carlotta Costa, carlotta.costa[ät]novartis.com