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Master’s thesis: Application of genetically encoded tension sensor modules to pancreatic cancer organoids

The aim of this thesis is to establish a new method for the measurement of molecular forces by applying tension sensors based on FRET to pancreatic cancer organoids. Confocal microscopy and digital imaging processing and analysis will be employed to understand how mechanical forces lead to structure formation processes in organmorphogenesis.

Your Profile:
• Surpassing grades in your master’s program in biology, (bio)chemistry, biotechnology, physics, or related scientific program
• Genuine interest in the powerful applications of cancer organoids and FLIM-FRET imaging
• Previous experience with fluorescence microscopy
• Advanced programming skills (Phython, matlab,…) for image data processing
• The ability to be self-motivated and to work independently within an interdisciplinary team of biotechnologists and physicist
• English language and organizational skills

Contact: M.Sc. Sophie Kurzbach, sophie.kurzbach[ät]tum.de

Link: https://www.bauschlab.org/