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Master thesis proteomics

in collaboration with the IMP Protein Chemistry group of Karl Mechtle

Our Groups.

As a shared thesis project of the PreOmics GmbH in Martinsried near Munich and the IMP Protein Chemistry Facility in Vienna, the proposed thesis provides the opportunity to experience and work in two exceptional working environments:

PreOmics GmbH, founded in 2016, is an innovative manufacturer of life science tools for the field of mass spectrometry. The PreOmics R+D team continuously aspires to develop innovative technologies and tools to revolutionize sample preparation for mass spectrometry applications. PreOmics is ranking 47 in Top 100 Growth Champions in Germany and 2nd for Chemistry and Pharma according to a survey by FOCUS-BUSINESS and Statista.

The IMP Protein Chemistry group of Karl Mechtler are dedicated experts in mass spectrometry-based proteomics. Working with state-of-the-art instruments, they constantly aim to develop new and powerful methods to increase sensitivity in protein identification, accuracy and precision of protein quantification or post-translational modification detection.

The Project.

We are looking for a highly motivated MSc student in the field of proteomics – focusing on homogenization efficiency of low quantity tissue and plant samples for LC-MS-based proteomics applications.

Aim of the present thesis project is to improve and optimize the homogenization and protein extraction efficiency of tissue and plant lysis using novel lysis technologies in comparison to classical homogenization methods. Based on a new patent-pending technology, the thesis will focus on the overall protein extraction and sample preparation workflow of tissue and plant samples with particular focus on low-quantity samples for the subsequent mass spectrometry-based proteomic analysis. Particular focus of the project will be on the analysis of low-quantity samples and increasing sensitivity in protein identification.

The proposed project is scheduled to be completed within one year. Nine months of the thesis are performed at the PreOmics GmbH (Martinsried near Munich, Germany) focusing on the improvement and optimization of the overall sample preparation workflow while working in close collaboration with Karl Mechtler. In the final stage of the work, three months will be held in Vienna to complete the project and acquire final data for a potential publication and the introduction of the optimized workflows at the Mechtler lab.

The Candidate.

The successful candidate should hold a BSc degree in the fields of chemistry, biochemistry, pharmaceutics, biology, or a related field. Advanced knowledge in liquid chromatography mass spectrometry as well as hands-on experience in sample preparation methods especially lysis and tissue homogenization are a prerequisite. Basic knowledge in data analysis including database searches and software for quantitative proteomics is desirable.

We are looking for a highly motivated candidate that is curious and interested in acquiring new skills as well as excited about working with and on new inventive technologies. Our ideal candidate should also have distinct team working abilities and an independent working mentality. Excellent written or spoken English language skills are a must, German skills will be an advantage.

Your application should include a motivation letter, your CV and the contact details of at least one reference. Please apply via our application form at https://preomics-gmbh-jobs.personio.de/job/283521#apply