We are looking for a BSc student for a 3 month thesis project entitled “The effect of different wash steps on the tissue metabolome in DESI-MSI”. Wash steps are frequently applied to tissue sections prior to mass spectrometry imaging (MSI) analysis to increase sensitivity for some compounds through the removal of some of the matrix compounds (for instance a xylene wash to remove lipids can increase abundance of highly hydrophilic compounds such as adenosine. However, a systematic assessment of the changes in the metabolome by DESI-MSI has not been performed yet. The student will test different polar and non polar wash solutions, optimise the wash duration, and perform MSI analysis to characterise these changes.
You are our right candidate if you’re interested in biomedical applications of mass spectrometry, especially mass spectrometry imaging. We will work with tissue specimen, cryosectioning, classical histological tissue stains (H&E, IHC) as well as state-of-the-art MSI using the ambient method Desorption Electrospray Ionisation (DESI). This project requires a systematic way of working and attention to detail.
Please send your application including your CV and a transcript of records to: nicole.strittmatter[ät]tum.de. Please supply a reference if possible.