Kategorien
Abschlussarbeiten Praktika Stellenangebote

Immunological diabetes research

Short description:
1. Targeting RORγt/DHODH signaling in islet autoimmunity and Type 1 Diabetes
 2. The role of T cell-specific IL6Rα signaling in maintaining tissue immune homeostasis

Description:
1. We investigate the influence of RORγt/DHODH inhibition on Tregs and different T cell subsets in islet autoimmunity and T1D. Using various in vitro approaches and loss-of-function or T1D mouse models, we dissect the impact on Treg induction and the underlying mechanisms. In collaboration with a biopharmaceutical company, we apply drug candidates targeting these signaling pathways in vivo to different mouse models for T1D to study their effect on autoimmune activation and diabetes progression or prevention.
2. We investigate the crucial role of the high-affinity α-chain of the interleukin 6 receptor (IL6Rα) on CD4+T cells and Foxp3+ Tregs. Using different gain- and loss-of-function mouse models, we dissect the role of the IL6Rα and its complex interplay with other signaling molecules in maintaining Tregs. By that, we investigate how the IL6Rα on T cells contributes to maintaining tissue homeostasis, preventing aberrant immune activation and mediating cross-talk between tissues and immune cells which is important for the function of diabetes-relevant tissues.


Kontaktperson:
Hannah Hipp; Maike Becker – Helmholtz Zentrum München,

Email:
hannah.hipp[ät]helmholtz-muenchen.de

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Design of functional polymer systems for 4-D printing techniques

Is part of: Marie Skłodowska-Curie fellowship

Project description:
4D printing of stimuli sensitive polymers has the potential to introduce additional functionalities to a wide variety of practical applications and further to fabricate customized functional devices. Within this project photopolymers are developed comprising stimuli sensitive groups that change the network structure, network density, (thermo-)mechanical properties but also surface properties in response to external trigger. Taking advantage of the high reactivity and excellent mechanical properties, 3D printed stimuli sensitive polymers will be based on photopolymerization of (methyl-) methacrylates as well as on “click” chemistry, suitable for DLP (digital light processing) based printing processes. Advancing from investigations of 2D photopolymers, complex 3D architectures with smart functionality (e.g. self-healing, shape memory, etc.) will be manufactured by employing additive manufacturing techniques. The smart functionality based on stimuli-triggered dynamic bond cleavage and formation mechanisms of the polymers will be investigated and the potential and limitations of the designed architectures for different transformations (e.g. gripping of objects) and applications in soft robotics will be evaluated.

We provide
✓ Advanced research in a multi-disciplinary team
✓ Excellent contacts to industry as well as to national and international research organizations
✓ Additional educational program involving training schools, workshops and summer schools
✓ Flexible working hours, 40h per week
✓ Possibility to perform a PhD at the Montanuniversitaet Leoben

Link: pccl.at/karriere/jobangebote.html

Kontaktperson: (Priv.-Doz. DI) Dr. Sandra Schlögl: jobs[ät]pccl.at

Kategorien
Abschlussarbeiten Stellenangebote

Master’s Thesis: Catalytic Activation of Dinitrogen with bioinspired Complexes

Short: The overarching aim of the Mougel group research at ETH Zürich is to provide energy efficient strategies for the (electro)chemical transformation of small molecules such as nitrogen or carbon dioxide to high value-added products. Molecular catalysts allow for a high tunability of reaction active sites. We hereby take our inspiration from Nature, by aiming to mimic biological phenomena. For this work the focus of research is on synthesis, reactivity and catalytic testing of various complexes for the reduction of nitrogen.

Requirements:
– Majoring in chemistry with a focus on inorganic chemistry or catalysis
– Experience in advanced Schlenk techniques and handling the Glovebox
– Curiosity and interest in scientific problem solving
– Experience in working with IR, NMR, GC, SC-XRD or UV-Vis are beneficial

Students will learn:
– Synthesis of air sensitive ligands and complexes using Schlenk techniques
– Catalytic testing under inert conditions
– Advanced NMR and UV-VIS characterization


Application/contact:
We are looking forward to receiving your application via email to
– mstrauss[ät]ethz.ch and mougel[ät]inorg.chem.ethz.ch.
Additional application to TUM Auslandsbüro Chemie/ ETH Mobility.
Start: between February and May.

Link: https://mougel.ethz.ch/