Kategorien
Abschlussarbeiten Praktika Stellenangebote

Immunological diabetes research

Short description:
1. Targeting RORγt/DHODH signaling in islet autoimmunity and Type 1 Diabetes
 2. The role of T cell-specific IL6Rα signaling in maintaining tissue immune homeostasis

Description:
1. We investigate the influence of RORγt/DHODH inhibition on Tregs and different T cell subsets in islet autoimmunity and T1D. Using various in vitro approaches and loss-of-function or T1D mouse models, we dissect the impact on Treg induction and the underlying mechanisms. In collaboration with a biopharmaceutical company, we apply drug candidates targeting these signaling pathways in vivo to different mouse models for T1D to study their effect on autoimmune activation and diabetes progression or prevention.
2. We investigate the crucial role of the high-affinity α-chain of the interleukin 6 receptor (IL6Rα) on CD4+T cells and Foxp3+ Tregs. Using different gain- and loss-of-function mouse models, we dissect the role of the IL6Rα and its complex interplay with other signaling molecules in maintaining Tregs. By that, we investigate how the IL6Rα on T cells contributes to maintaining tissue homeostasis, preventing aberrant immune activation and mediating cross-talk between tissues and immune cells which is important for the function of diabetes-relevant tissues.


Kontaktperson:
Hannah Hipp; Maike Becker – Helmholtz Zentrum München,

Email:
hannah.hipp[ät]helmholtz-muenchen.de

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Design of functional polymer systems for 4-D printing techniques

Is part of: Marie Skłodowska-Curie fellowship

Project description:
4D printing of stimuli sensitive polymers has the potential to introduce additional functionalities to a wide variety of practical applications and further to fabricate customized functional devices. Within this project photopolymers are developed comprising stimuli sensitive groups that change the network structure, network density, (thermo-)mechanical properties but also surface properties in response to external trigger. Taking advantage of the high reactivity and excellent mechanical properties, 3D printed stimuli sensitive polymers will be based on photopolymerization of (methyl-) methacrylates as well as on “click” chemistry, suitable for DLP (digital light processing) based printing processes. Advancing from investigations of 2D photopolymers, complex 3D architectures with smart functionality (e.g. self-healing, shape memory, etc.) will be manufactured by employing additive manufacturing techniques. The smart functionality based on stimuli-triggered dynamic bond cleavage and formation mechanisms of the polymers will be investigated and the potential and limitations of the designed architectures for different transformations (e.g. gripping of objects) and applications in soft robotics will be evaluated.

We provide
✓ Advanced research in a multi-disciplinary team
✓ Excellent contacts to industry as well as to national and international research organizations
✓ Additional educational program involving training schools, workshops and summer schools
✓ Flexible working hours, 40h per week
✓ Possibility to perform a PhD at the Montanuniversitaet Leoben

Link: pccl.at/karriere/jobangebote.html

Kontaktperson: (Priv.-Doz. DI) Dr. Sandra Schlögl: jobs[ät]pccl.at

Kategorien
Abschlussarbeiten Stellenangebote

Master’s Thesis: Catalytic Activation of Dinitrogen with bioinspired Complexes

Short: The overarching aim of the Mougel group research at ETH Zürich is to provide energy efficient strategies for the (electro)chemical transformation of small molecules such as nitrogen or carbon dioxide to high value-added products. Molecular catalysts allow for a high tunability of reaction active sites. We hereby take our inspiration from Nature, by aiming to mimic biological phenomena. For this work the focus of research is on synthesis, reactivity and catalytic testing of various complexes for the reduction of nitrogen.

Requirements:
– Majoring in chemistry with a focus on inorganic chemistry or catalysis
– Experience in advanced Schlenk techniques and handling the Glovebox
– Curiosity and interest in scientific problem solving
– Experience in working with IR, NMR, GC, SC-XRD or UV-Vis are beneficial

Students will learn:
– Synthesis of air sensitive ligands and complexes using Schlenk techniques
– Catalytic testing under inert conditions
– Advanced NMR and UV-VIS characterization


Application/contact:
We are looking forward to receiving your application via email to
– mstrauss[ät]ethz.ch and mougel[ät]inorg.chem.ethz.ch.
Additional application to TUM Auslandsbüro Chemie/ ETH Mobility.
Start: between February and May.

Link: https://mougel.ethz.ch/

Kategorien
Allgemein Sonstige Stellenangebote Stellenangebote

Oberflächenanalytik für Doktoranden/Post-Docs

Beschreibung:
Mehrere mögliche Stellenangebote zum Thema Oberflächenspannung. ,,Auf Wunsch unterstützen wir auch Doktoranden/Post-Docs/wissenschaftliche Mitarbeiter auch gerne im Bewerbungsprozess, beispielsweise durch die Beratung zum Thema Bewerbungsunterlagen sowie zum Ablauf eines Bewerbungsgespräches bei Industrieunternehmen.“

Genauere Informationen zu den einzelnen Stellen:

Kontakt für die Beratung : Ilka.Sorge[ät]professional-scientists.de

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Doctoral researcher (m/f/d) in marine chemical sensor development

The research unit „Chemical Oceanography“ of the research division „Marine Biogeochemistry“ at GEOMAR invites applications for a Ph.D. position on the development of a chemical sensor for the measurement of dissolved inorganic carbon (DIC) in seawater.The candidate will work in thelarge consortium ’AIMS3’that forms part of the German DAM (Deutsche Allianz Meeresforschung) Mission on ‘Marine CarbonSinksinDecarbonizationPathways’. The DAM Mission will explore ocean carbon sink options and develop environmental monitoring approaches as part of thedecarbonization strategy. AIMS3 will develop improved environmental monitoring technologies for off-shore carbon capture and storage(CCS)sites, and will explore the possibility of CO2storage in deep ocean basalts. The candidate willdesign, develop and demonstrate a DIC sensor for monitoring CCS sites for potential CO2leaks. The PhD project will be conducted in close collaboration with a local marine technology company.The project will involve optimisation of sensor chemistry and detection technology, sensor miniaturisation and integration into existing physical sensor systems produced by the company. Laboratory and field testing and demonstrations form part of the project. The candidate will work closely with Prof. Dr. Eric Achterbergand Dr Mario Esposito, the local company, and other partners in AIMS3. The candidate will become part of the German DAM Mission ‘Marine Carbon Sinks in Decarbonization Pathways’, and in particular in the AIMS3 project. Regular fieldwork opportunities, including research cruises, will form part of the PhD project for testing and demonstration purposes. We expect the candidate to enrol in the marine science post-graduate school in Kiel, ISOS.

Kategorien
Promotions-/PhD-Stellen Stellenangebote

PhD Position – Molecular Immunology & Experimental Oncology

Description:
Two open PhD positions are available at the Institute of Molecular Immunology & Experimental Oncology, Technical University of Munich.The institute addresses important questions about the regulation of immunity against hepatotropic infections and tumors in mice and men. Preclinical models are applied to investigate detailed mechanistic principles about anti-viral and anti-cancer immunity. Both projects are based on the identification of a novel T cell population that has tissue-destructive function (Dudek et al. Nature 2021). The third-party funded projects (DFG and Helmholtz) will investigatevirus-specific immunity against hepatitis B Virus infection and SARS-CoV-2 infection and how tissue-destructive T cells contribute to immune surveillance or immune pathology.


Kategorien
Abschlussarbeiten Stellenangebote

Bachelor Arbeit – Biozid-Analytik in Kühlschmiermitteln

Kurzbeschreibung:
Es soll eine LC/UV Methode für die quantitative Bestimmung von 3 Bioziden (Pyrithion, BIT, BBIT) in Kühlschmiermitteln (KSS) entwickelt und für unterschiedliche KSS valdidiert werden.

Beschreibung:
Kühlschmiermittel werden in der Metallverarbeitenden Industrie in vielen Prozessen eingesetzt und bestehen aus einer Öl/Wasser-Mischung. Leider bietet diese Mischung einen guten Nährboden für Mikroorganismen, die für schlechte Gerüche und veränderte Kühl- und Schmiereigenschaften sorgen können, sowie potentielle gesundheitliche Gefahren verursachen können. Um das Wachstum zu der Mikroorganismen zu verhindern, werden meist Biozide in Stoßdosierungen eingesetzt. Durch eine neue Dosierungsstrategie soll eine konstante geringe Dosierung ermöglicht werden, die kontinuierlich das Wachstum verhindern kann. Hierzu soll eine begleitende Analytik mittels Flüssigchromatographie-UV/VIS-Detektion entwickelt und für verschiedene Kühlschmiermittel validiert werden.

Kontaktperson: Dr. Oliver Knoop, oliver.knoop[ät]tum.de

Link: https://www.bgu.tum.de/sww/startseite/

Kategorien
Abschlussarbeiten Stellenangebote

Bachelorarbeit – Siedlungswasserwirtschaft

Kurzbeschreibung:
Für die Untersuchung verschiedener Fragestellungen wird eine zuverlässige Bestimmungsmethode für volatile Grundwasserschadstoffe der BTEX-Gruppe benötigt. Hier soll im Rahmen einer Bachelorarbeit eine Headspace-GC/FID-Methode etabliert und validiert werden.

Beschreibung:
BTEX (Benzol, Toluol, Ethylbenzol und p-, o-, und m-Xylol) sind häufig als Schadstoffe im Grundwasser anzutreffen, beispielsweise durch Leckagen an Tankstellen oder Ölförderarbeiten eingetragen. „Advanced Oxidation Processes“ (AOPs), beispielsweise Ozon mit Wasserstoffperoxid (O3/H2O2), ermöglichen eine gute Entfernung, jedoch ist der Transformationsmechanismus teilweise noch unbekannt. Für die Untersuchung verschiedener Fragestellungen wird eine zuverlässige Bestimmungsmethode für volatile Substanzen benötigt. Diese kann im Rahmen einer Bachelor- oder Studienarbeit eigenständig an einem Agilent 7980 GC-FID mit Headspace-Modul entwickelt werden.
Eine umfangreiche Einarbeitung und Betreuung werden gewährleistet. Grundlegende Kenntnisse der Gaschromatographie und ein weitergehendes Interesse an Analytik sind von Vorteil. Die Arbeit kann auf Englisch oder Deutsch abgefasst werden.

Kontakt: Emil Bein & Oliver Knoop
Email: emil.bein[ät]tum.de
Link: https://www.bgu.tum.de/sww/startseite/

Kategorien
Allgemein Promotions-/PhD-Stellen Stellenangebote

PhD position in the Zeymer group

Short:

The Zeymer group is looking for a dedicated and talented PhD student, who is interested in protein engineering, artificial metalloenzymes, and protein dynamics. The project is fully funded through the Collaborative Research Center „SFB1035“, a consortium of biochemists, structural biologists, and biophysicists at TUM and beyond focusing on the “Control of Protein Function by Conformational Switching”. If you are enthusiastic about science and wish to work on an exciting and challenging research project at the interface between Biochemistry and Biophysics, please apply directly by e-mail to Prof. Dr. Cathleen Zeymer.

Detailed:

The Zeymer Lab is a member of the Department of Chemistry and the newly established Center for Functional Protein Assemblies at TU Munich, Germany. We combine rational design and directed evolution to engineer artificial metalloenzymes and study their structure and molecular mechanism with various biophysical techniques.

We are currently looking for a dedicated and talented PhD student, who is interested in engineering conformational dynamics in a lanthanide-dependent de novo enzyme. The project is fully funded through the Collaborative Research Center SFB1035, a consortium of biochemists, structural biologists, and biophysicists focusing on the “Control of Protein Function by Conformational Switching”.

Candidates with a Master’s degree in Biochemistry, Chemistry, or Biology, who are highly motivated to learn about enzyme engineering, directed evolution, protein structure and dynamics are encouraged to apply. Previous practical experience in molecular cloning, protein expression and purification, as well as handling and characterizing (metallo-)enzymes will be of benefit.

If you are enthusiastic about science and wish to work on an exciting and challenging research project at the interface between Biochemistry and Biophysics, please apply directly by e-mail to Prof. Dr. Cathleen Zeymer. The application should include a cover letter, CV, transcript of records, and contact details to request two reference letters.

Contact:
E-Mail: cathleen.zeymer[ät]tum.de

Webside:
https://www.department.ch.tum.de/en/proteinchemie

Kategorien
Sonstige Stellenangebote Stellenangebote

Studentenjob – Mathenachhilfe

Kurz:
Mathe-Nachhilfelehrer gesucht. 15,- Euro pro Stunde, 75,- Euro pro Nachmittag möglich.

Bewerbung an: https://lehrer-casting.de


Kontakt: Wolfram Becker
Tel.: 089 5 999 7 333
E-Mail: service[ät]mathe-nachhilfe.com