Kategorien
Abschlussarbeiten Praktika Stellenangebote

Masterarbeit im Fachbereich Onkologie

[english below] Wir bieten ein spannendes Projekt an der Schnittstelle von Zellbiologie und Medizin im Bereich Pankreaskarzinomforschung an. Das duktale Adenokarzinom des Pankreas (PDAC) ist durch ein fibroblastenreiches desmoplastisches Stroma gekennzeichnet, dass eine kritische Rolle bei der Progression und Therapieresistenz des PDAC spielt. Dieses Projekt wird sich auf die Interaktion zwischen CAF (Tumor-assoziierte Fibroblasten) und PDAC-Zellen im humanen Zellkultursystem konzentrieren und aufklären, wie die CAFs die Aggressivität von PDAC-Zellen durch verschiedene Mechanismen fördert und neue Therapiekonzepte abgeleitet werden.

We offer an exciting project at the interface of cell biology and medicine in pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma which plays a critical role in the progression and therapeutic resistance of PDAC. The stroma is composed of extracellular matrix proteins, mainly deposited by the cancer-associated-fibroblasts (CAFs) and various types of immune cells. Cancer-associated fibroblasts display a high degree of interconvertible states including quiescent, inflammatory and myofibroblastic phenotypes. However, the mechanisms by which this plasticity is achieved are poorly understood.

This project will focus on the CAF – PDAC cell interaction in the human cell culture system and will elucidate how CAF plasticity promotes PDAC cell aggressiveness through multiple mechanism.

Our spectrum of methods we can offer

  • Cell culture
  • Working with primary human and murine cell lines (organoids)
  • Drug screens
  • Co-Culture systems
  • Manipulation of human und murine cell lines (CRISPR Cas9, etc.)
  • Broad spectrum of molecular biology (ELISA, Western Blot, PCR, Cloning of Plasmids)
  • Flow cytometry
  • Orthotopic Implantation (mouse models)
  • Imaging (MRT, PET)

Contact:

For further details please contact Dr. Karin Feldmann (karin.feldmann[ät]tum.de; AG Reichert | Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, TUM)

Kategorien
Aktuelles Event Sonstige Stellenangebote Stellenangebote Veranstaltungen

Teach First Deutschland

Teach First Deutschland (TFD) engagiert sich gemeinsam mit 58 weiteren unabhängigen Länderorganisationen global im internationalen Netzwerk Teach For All für Bildungsgerechtigkeit und Chancengleichheit. Die Schirmherrin der bundesweit organisierten Bildungsinitiative ist Elke Büdenbender, Ehefrau des Deutschen Bundespräsidenten Frank-Walter Steinmeier.

Für das Leadership-Programm von TFD können sich Hochschulabsolvent_innen aller Studienfachrichtungen bewerben. Insgesamt sind auch dieses Jahr wieder 160 begehrte Plätze für die Bundesländer Sachsen, Nordrhein-Westfalen, Berlin, Baden-Württemberg, Hessen, Hamburg und Schleswig-Holstein zu vergeben, wir rekrutieren hierzu bundesweit. Weitere Infos und Eindrücke zu Organisation und Programm sind auf unserer Homepage zu finden bzw. in unserem Imagefilm präsentiert, der unseren und den Einsatz der Fellows ziemlich gut auf den Punkt bringt.

In dieser Woche rekrutieren wir gezielt in München, weshalb Euch als FSR diese Mail erreicht.In der angehängten Stellenausschreibung, die sehr gerne mit den Studierenden der Fachschaft geteilt werden darf, finden sich weitere Informationen zum Bewerber_innenprofil und Programm von TFD. Zudem bietet Teach First Deutschland im Januar eine kostenlose Webinar-Reihe für Studierende mit drei Themen an. Die Übersicht der Webinare habe ich Euch ebenfalls angehängt. Ich würde mich freuen, wenn die Webinarbroschüre mit den Studierenden eurer Fachschaft geteilt wird. Weiterhin und zuletzt möchten Wir Euch und weitere Interessierte gern zu unserer Veranstaltung „Meet a Fellow“ einladen. Dabei stellt ein/e Fellow ihren/seinen Einsatz vor und Du hast die Möglichkeit, Fragen zu stellen. Wähle Dich dazu einfach am 21. Januar um 17.30 Uhr unter diesem Link ein.

14.01.
21.01.
21.01.
28.01.
14.03.
16:00 Uhr – Webinar: “Value-Based Leadership“
16:00 Uhr – Webinar: “Umgang mit komplexen Herausforderungen“
17:30 Uhr – “Meet a Fellow”
16:00 Uhr – Webinar: “Situational Leadership”
Nächste Bewerbungsfrist Leadership-Programm
Kategorien
Aktuelles Event Veranstaltungen

Discover DSM

The business course provides young talents in Operations | Technology | Supply Chain | Engineering the opportunity to get to know DSM from the inside together with 30 international students. Via MATCH! we recruit a number of candidates for our traineeships.


For the promotion of the business course, we organize 5 digital lectures (between January 18th and February 5th) given by DSM experts / business leaders on the following topics:

Purpose-led Innovation within DSM  
Digitalization and Advanced Analytics in production
How is DSM improving their own greenhouse gas efficiency?
DSM’s journey towards a fully sustainable value chain
DSM’s contribution to a meat-less world
Kategorien
Aktuelles Event Veranstaltungen

Think .Make.Start #12

Do you want to learn how to act and work like the most successful innovators?

Do you want to meet and work with students from all over TUM to solve real problems?

Do you want to apply your skills to build new products in only two weeks using latest technology?

Then it is time for Think.Make.Start (TMS) !

50 students | All disciplines | 2 weeks | 6 ECTS

In March 2021 (12.03 – 30.03.21) the interdisciplinary innovation format Think.Make.Start (TMS) will take place again. You will have the opportunity to work on real product ideas with students from other departments. The course is open to students from all disciplines and is worth 6 ECTS (completed bachelor’s program recommended).

You can find more information and apply until January 29th via: https://apply.thinkmakestart.com/ If you have any questions you can contact us via info[ät]thinkmakestart.com

Kategorien
Abschlussarbeiten Stellenangebote

Master Thesis NMR & Batteries

Interested to work on an interdisciplinary project at the interface of new NMR technologies and batteries?

Recent experiments have shown that defects in diamond can be used as quantum sensors for detecting NMR (nuclear magnetic resonance) signals from tiny volumes down to a single molecule!

This new technology will be used here for NMR spectroscopy to probe batteries in situ. In particular, we would like to monitor ion diffusion in batteries on the microscopic scale, which is of central importance for their function. Pulsed-field-gradient (PFG) NMR is a common method used for measuring atomic and molecular diffusion. However, it cannot detect low diffusion coefficients such as they occur in batteries due to limited available magnetic gradient strength7. In contrast, the microscopic NMR detection volume of NVs will allow the application of several orders of magnitude high magnetic field gradients over the sample volume. This will not only make it possible to measure very low diffusion coefficients but also to monitor unprecedented ultrashort diffusion length on the nanometer range. This will result in the determination of ion diffusion coefficients at interfaces, which cannot be obtained with current methods.

Tasks: Design and fabricate diamond sensor with integrated gradient coils for probing batteries.

Techniques: 3D-printing, electronics, NV-quantum sensing, NMR, chemistry

Skills: Ideally some knowledge of batteries and/or NMR spectroscopy.

Contact dominik.bucher[ät]tum.de

Kategorien
Abschlussarbeiten Stellenangebote

Master Thesis NMR & Catalysis

Interest to work at an interdisciplinary project at the interface of new NMR technologies and chemistry/catalysis?

Recent experiments have shown that defects in diamond, in particular nitrogen-vacancy (NV) centers, can be used as quantum sensors for detecting nuclear magnetic resonance (NMR) signals from tiny volumes down to a single molecule!

NV-NMR is paving the way for high-sensitivity real-time monitoring of chemical reactions on surfaces at the nanoscale in a totally non-invasive and non-destructive way. A natural application of such a new tool is the study of heterogeneous photocatalytic systems, where light-driven reactions take place on the surface and where very often the formation of short-lived radical species is crucial for the functioning of the catalytic cycle.

In this interdisciplinary project at the interface of Quantum sensing, Electron Paramagnetic Resonance (EPR) spectroscopy, chemistry and catalysis you will use NV-shallow-implanted diamond chips as sensing platforms on which to perform photocatalytic reactions to be monitored in real-time at room temperature. For the purpose you will implement NV-based-relaxometry experiments based on laser/LED light excitation as well as on spin-manipulation by microwave fields. This will enable the measurement of the relaxation times of the NV-electron spins being perturbed by the interacting intermediates during the catalytic process. This will allow to get crucial insight on the overall heterogeneous catalysis mechanism at the nanoscale.

Tasks: Putting into operation an optimized setup for NV-based experiment

Techniques: NV-NMR, Chemistry.

Skills: Ideally knowledge of NMR/EPR spectroscopies, physical chemistry and spectroscopy, inorganic chemistry and catalysis.

Contact dominik.bucher[ät]tum.de
The lab is located at the TUM Chemistry department (Physical Chemistry). For more information: www.bucherlab.org

Kategorien
Abschlussarbeiten Stellenangebote

Master Thesis NMR & Life Sciences

Interested to work on an interdisciplinary project at the interface of new NMR technologies and life science?

Recent experiments have shown that defects in diamond, in particular nitrogen-vacancy (NV) centers, can be used as quantum sensors for detecting nuclear magnetic resonance (NMR) signals from tiny volumes down to a single molecule!

NV-NMR is paving the way for NMR analysis on the single-cell level enabling us to study metabolites and metabolic states of single living cells in a non-invasive and non-destructive way. To achieve this highly ambitious goal and due to the inherently low sensitivity of NMR, we employ so-called hyperpolarization schemes resulting in an exceptional enhancement of the NMR signal. A promising technique for breaking the sensitivity limitations of NMR is hyperpolarization of nuclear spins by parahydrogen induced polarization (PHIP). In these schemes the transfer of the non-thermal singlet spin order of parahydrogen to the target substrate leads to several orders of magnitude NMR signal amplification. This can be achieved either by direct hydrogenation of the thermally polarized precursor or by transiently binding parahydrogen and substrate to an organometallic catalyst. The latter scheme is known as signal amplification by reversible exchange (SABRE).

In this highly interdisciplinary Project at the interface of (quantum)physics, chemistry and biology you will put a cryostat for the production of parahydrogen into operation and use the PHIP or SABRE scheme for the hyperpolarization of interesting metabolites. Furthermore, you will learn how to use diamonds to detect nuclear magnetic resonances and record NV-NMR spectra of your hyperpolarized substrates. At last you will monitor the metabolism of single cells.

Tasks: Putting into operation a cryostat for the production parahydrogen, perform PHIP on a microfluidic chip

Techniques: NV-NMR, PHIP Hyperpolarization, Chemistry, Cell biology, Microtechnology

Skills: Ideally knowledge in NMR or hyperpolarization, chemistry and (bio)physics.

Contact dominik.bucher[ät]tum.de
The lab is located at the TUM Chemistry department (Physical Chemistry). For more information: www.bucherlab.org

Link: http://www.bucherlab.org

Kategorien
Promotions-/PhD-Stellen Stellenangebote

Absolventenstellen professional scientists GmbH

Professional Scientists ist Deutschlands erstes, konsequent auf die Vermittlung von wissenschaftlichen Mitarbeitern spezialisiertes Personaldienstleistungsunternehmen.

www.professional-scientists.de

Dort findet ihr Stellen für den Einstieg in die Wirtschaft aus den Bereichen Chemie, Physik und Materialwissenschaften.

Kategorien
Promotions-/PhD-Stellen Stellenangebote

PhD position:

Dynamical pathways of N-heteropolycycles in the strong light-matter coupling regime.

Polaritonic chemistry seeks to modify reactivity and structure through coupling to the quantized photonic modes of resonance cavities. The field is in its infancy but growing quickly. In this PhD project, we will learn how to modify singlet fission and other energy transfer mechanisms in cavities from a first-principles quantum molecular dynamics perspective.

A fully funded PhD position is available in the Theoretical Chemistry Group, Heidelberg University, within the recently extended SFB 1249 (N-Heteropolyzyklen als Funktionsmaterialen) for the period 2021-2024.

Possible starting date: Sommer semester 2021 or earlier.

The strong light-matter coupling regime provides new opportunities to steer and control the structure and dynamics of molecular systems. Much progress in our group has been made towards simulating ultrafast dynamical processes in small molecules by quantum dynamics approaches. The main goal of this project is to discover general strategies to modify the process of singlet fission in N- heteropolycycles by exploiting the coupling to the photonic modes of a resonance cavity. The project involves the usage and further development of state-of-the-art quantum dynamics methods, as well as close interaction with the experimental groups in the consortium.

Kategorien
Aktuelles Event Veranstaltungen

Studium – und dann?

+++ english version below +++

Hiermit möchten wir euch herzlich zu einer neuen Runde unseres Webinars „TUM Chemistry Career Perspectives“ einladen!

Worum geht es?

Chemieabsolventen, die irgendwo zwischen Anfang und Mitte ihres Berufslebens stehen, berichten aus erster Hand: Aus ihrem beruflichen Alltag, wie sie dorthin gekommen sind und was von den Dingen, die man an der Universität und anderswo lernt, eigentlich wirklich nützlich ist – auch abseits der üblichen Pfade.
Was habe ich davon? Konkrete Einblicke in den Arbeitsalltag von Leuten mit chemischem Abschluss – sowohl Master als auch Doktor. Neben einem Vortrag mit Beispielen, wie es nach dem eigenen Abschluss weitergehen könnte, erhalten Teilnehmer hier die Möglichkeit, alle Fragen zu stellen, die man schon immer gerne beantwortet hätte (z.B. Berufseinstieg, Bewerbung, Karriereplanung etc.).

Wer, Wann und Wo?

Jeweils ein Termin im Dezember, Januar und Februar als Webinar auf Zoom.

Für den ersten Termin haben wir als Speaker eingeladen: Dr. Lisa Steinhauser (Technical Support Manager at Showa Denko Europe GmbH & Wissenschaftscoach) am Dienstag, 15.12.2020 um 17 Uhr c.t. Die weiteren Termine und Speaker sind auf dem Plakat im Anhang zu finden. Die Webinar-Zugangsdaten veröffentlichen wir dann zeitnah hier.

Thema: TUM Chemistry Career Perspectives – Speaker: Dr. Lisa Steinhauser (Vortrag auf Englisch)

Zoom-Meeting beitreten
https://tum-conf.zoom.us/j/97040377901
Meeting-ID: 970 4037 7901
Kenncode: 020106

Wir freuen uns auf euch,
Beste Grüße!

+++ english version +++

We would like to cordially invite you to the next round of our speakers’ series webinar “TUM chemistry career perspectives”!

What is it about?

Chemistry graduates who currently stand somewhere between the starting and the middle of their career phase will provide first-hand insights: from their everyday working life, how they made their way and also about what of the things you’ve learned at the university and elsewhere are really useful – also following unusual paths.
What’s in it for me? Gaining detailed insights into working life of people with a chemistry degree – both Master as well as PhD. Besides a talk providing an example on how you could proceed after your own graduation, participants have the opportunity to ask every question they were always wondering about (e.g. on career entry, application process, career planning, etc.).

Who, when and where?

Dates are scheduled for December, January and February (one each) as a webinar on Zoom. For the upcoming event, we have as invited speakers: Dr. Lisa Steinhauser (Technical Support Manager at Showa Denko Europe GmbH & science coach) on Tuesday, 15th of December 2020 at 5:15 pm. The further upcoming dates and speakers can be found on the poster attached.

Topic: TUM Chemistry Career Perspectives – Speaker: Dr. Lisa Steinhauser (Talk is held in English language)

Enter Zoom-meeting
https://tum-conf.zoom.us/j/97040377901
Meeting-ID: 970 4037 7901
password: 020106

Best wishes!